Enhanced drug loading efficiency of contact lenses via salt-induced modulation

Ophthalmic drug delivery through contact lenses.

PURPOSE Currently available ophthalmic drug delivery systems are inefficient and may lead to side effects. To increase efficiency and reduce side effects, the authors propose disposable particle-laden soft contact lenses for ophthalmic drug delivery. METHODS The essential idea is to encapsulate the ophthalmic drug formulations in nanoparticles and to disperse these drug-laden particles in the...

Drug delivery through soft contact lenses.

Clinical studies were conducted on 466 patients waiting for senile cataract surgery and receiving chloromycetin, gentamicin, or carbenicillin subconjunctivally and through New Sauflon 70 and New Sauflon 85 lenses. The aqueous drug levels were biologically estimated at various time intervals. Soft contact lenses provided significantly higher drug penetration than subconjunctival therapy. Both mo...

Therapeutic Contact Lenses via Biomimetic Imprinting

A biomimetic approach has been exercised to design and synthesize novel contact lenses, to tackle the unmet need for the controlled loading and release of therapeutics on the surface of the eye. This work will demonstrate the formation and characterization of novel lenses with controlled loading and release of ocular H1antihistamines and antibiotics. Since ocular bioavailability of topical drug...

[contact Lenses].

Novel Approaches in Formulation and Drug Delivery using Contact Lenses

The success of ocular delivery relies on the potential to enhance the drug bioavailability by controlled and extended release of drug on the eye surface. Several new approaches have been attempted to augment the competence and diminish the intrinsic side effects of existing ocular drug delivery systems. In this contest, progress has been made to develop drug-eluting contact lens using different...